The development of a 4th generation biosensors is necessary to benefit from the high activity and natural selectivity of biological entities combined with electronic transducers. Reaching these goals will allow monitoring precisely the concentration of specific biomarkers and triggering the redox reaction of important molecules and macro-molecules, controlling their activity in-vivo. These molecular architectures are of tremendous importance for the development of next generation biotechnological instruments including health sensors for point of care and implantable devices, and for energy conversion systems such as biofuel cells.
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From the beggining
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Where we are now |
This project aimed to acquire more knowledge on long-term operational stability of bio- electrochemical systems. The long-term goal is to dynamically stimulate the electrochemical interface to preserve and to increase the operational stability and activity of those systems. IN order to do so, we establish a biocompatible electrified interface using renewable materials.
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We successfully used fluorescent carbon nanoparticles whose biocompatible properties are establish, thus providing a solid basis for the development of implantable devices. The second objective aimed to study the influence of alternating electrical polarization waveform frequencies on the bio-electrochemical reaction yields, and thus to interrogate the validity of continuous polarization in bio-electrochemical sciences. The final goal of the proposal proposed a novel electroanalytical technic based on the stochastic stimulation of the electrical interface mimicking thermal stochastic fluctuations.
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Fluorescent carbon nanoparticles (CDots) are widely used as chemical sensor, solar cells sensitizer, light-emitting diode, for bioimaging in nanomedicine, and for electrocatalysis. They can be readily prepared by microwave pyrolysis or hydrothermal method. CDots present versatile physical and chemical properties like photoluminescence, catalytic and biocompatible properties.
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